基本信息：
張黎?。?983.03-），博士，講師，碩士生導(dǎo)師。研究方向為免疫模式動物及免疫炎癥相關(guān)研究，主要從事T細(xì)胞抗血吸蟲病的作用機(jī)制以及免疫細(xì)胞在動脈粥樣硬化形成中的機(jī)制研究。主持國家自然科學(xué)基金面上項目1項、主持完成國家自然科學(xué)基金青年項目1項及河南省科技攻關(guān)計劃項目1項。作為免疫表型組學(xué)中心的骨干成員，主要負(fù)責(zé)動物遺傳模型的設(shè)計構(gòu)建以及細(xì)胞系基因編輯技術(shù)的研發(fā)。
教育經(jīng)歷：
(1)2008-09至2011-11, Aix-Marseille University（法國艾克斯-馬賽大學(xué)）,微生物學(xué),博士,微生物學(xué)，導(dǎo)師：Cheng-Cai Zhang
(2)2006-09至2008-08,華中農(nóng)業(yè)大學(xué),微生物學(xué),碩博連讀,農(nóng)業(yè)微生物學(xué)國家重點實驗室，藍(lán)細(xì)菌分子生物學(xué)，導(dǎo)師：陳雯莉
(3)2002-09至2006-06,華中農(nóng)業(yè)大學(xué),生物科學(xué),理學(xué)學(xué)士,國家生物學(xué)理科基地班
科研與學(xué)術(shù)工作經(jīng)歷：
(1)2013-11至現(xiàn)在,新鄉(xiāng)醫(yī)學(xué)院,醫(yī)學(xué)檢驗學(xué)院,講師
(2)2013-03至2013-09,法國馬賽免疫中心(CIML), Bernard MALISSEN法國科學(xué)院院士實驗室,博士后, T細(xì)胞活化相關(guān)功能基因的研究
(3)2012-05至2013-02,法國地中海微生物研究所（IMM-LCB）, Long-Fei Wu實驗室,博士后,在新型趨磁細(xì)菌中建立其遺傳轉(zhuǎn)化體系
主持或參加科研項目情況:
(1)國家自然科學(xué)基金委員會,面上項目,磷酸酶Ptprc突變激活CD36/Vav/JNK信號軸促進(jìn)泡沫細(xì)胞分化的機(jī)制, 2022-01至2025-12, 58.0000萬元,主持
(2)國家自然科學(xué)基金委員會,青年項目, 81601360, T細(xì)胞對非適應(yīng)性宿主抗血吸蟲病的作用, 2017-01至2019-12, 17.5000萬元,已結(jié)題,主持
(3)國家自然科學(xué)基金委員會,面上項目, 32070898, LAT介導(dǎo)的負(fù)反饋障礙導(dǎo)致T細(xì)胞增殖失控的機(jī)制, 2021-01至2024-12, 58.0000萬元,在研,參加
(4)國家自然科學(xué)基金委員會,面上項目, 81471595, CD28缺失加劇NOD小鼠T細(xì)胞活化的機(jī)制研究, 2015-01至2018-12, 70.0000萬元,已結(jié)題,參加
(5)國家自然科學(xué)基金委員會,面上項目, 81471559, Bcl3對HTLV-1病毒感染細(xì)胞內(nèi)NFκB通路和細(xì)胞自噬作用的分子機(jī)制, 2015-01至2018-12, 75.0000萬元,已結(jié)題,參加
代表性研究成果（#為第一作者，*為通訊作者）：
(1)Liaoxun Lu#; Junjian Hu#; Tianzhu Chao; Zhijun Chen; Zhuangzhuang Liu; Xinsong Luo; Yinming Liang; Pei He*;Lichen Zhang*;Loss of natural resistance to schistosome in T cell deficient rat,PLoS Neglected Tropical Diseases, 2020; 14(12): e0008909.
(2)Rong Huang#; Guo Guo#; Liaoxun Lu#; Rui Fu; Jing Luo; Zhuangzhuang Liu; Yanrong Gu; Wenyi Yang; Qianqian Zheng; Tianzhu Chao; Le He; Ying Wang; Zhiguo Niu; Hui Wang; Toby Lawrence; Marie Malissen; Bernard Malissen; Yinming Liang*;Lichen Zhang*;The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis,The Journal of Lipid Research, 2019; 60(12): 2006-2019.
(3)Luo Jing#; Liaoxun Lu#; Yanrong Gu; Rong Huang; Lin Gui; Saichao Li; Xinhui Qi; Wenping Zheng; Tianzhu Chao; Qianqian Zheng; Yinming Liang*;Lichen Zhang*;Speed genome editing by transient CRISPR/Cas9 targeting and large DNA fragment deletion,Journal of Biotechnology, 2018;281: 11-20.
(4)Guillaume Voisinne; Kristof Kersse; Karima Chaoui; Liaoxun Lu; Julie Chaix;Lichen Zhang; Marisa Goncalves Menoita; Laura Girard; Youcef Ounoughene; Hui Wang; Odile Burlet-Schiltz; Hervé Luche; Frederic Fiore; Marie Malissen; Anne Gonzalez de Peredo; Yinming Liang*; Romain Roncagalli*; Bernard Malissen*;Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics,Nature Immunology, 2019; 20(11): 1530-+.
(5)Tianzhu Chao#; Liaoxun Lu#;Lichen Zhang#; Rong Huang; Zhuangzhuang Liu; Binhui Zhou; Eryan Kong; Zhongjian Zhang; Toby Lawrence*; Yinming Liang*;An inducible model for specific neutrophil depletion by diphtheria toxin in mice,Science China Life Sciences, 2021;64(8):1227-1235.
(6)Zhang Lichen, Li Wushan, Liu Zhuangzhuang, Liu Yang, Liu Zhilong, Gu Yanrong, He Le, Zhou Binhui, Li Tianhan, Chao Tianzhu, Liang Yinming*, Lu Liaoxun*: sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification.Frontiers in Cell and Developmental Biology, 2021;9:769673.
(7)Lichen Zhang, Rong Huang, Liaoxun Lu, Rui Fu, Guo Guo, Yanrong Gu, Zhuangzhuang Liu, Le He, Marie Malissen, Yinming Liang*; Gene Knock-in by CRISPR/Cas9 and Cell Sorting in Macrophage and T Cell Lines,Journal of Visualized Experiments, 2021;DOI: 10.3791/62328-v
(8)Shicong Zhai#; Cui Liu#;Lichen Zhang; Jian Zhu; Jiqiang Guo; Jinghang Zhang; Zhijun Chen; Wenping Zhou; Tingmin Chang; Siguang Xu; Yijun Qi; Ting Zhuang; Na Yu; Weilong Wang; Hui Wang; Sifan Yu; Xiumin Li*;PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail,NEOPLASIA, 2017;19(3): 154-164.
(9)Liaoxun Lu#*; Tianhan Li#; Xinyu Feng; Zhilong Liu; Yang Liu; Tianzhu Chao; Yanrong Gu; Rong Huang; Fanghui Zhang; Le He; Binhui Zhou; Eryan Kong; Zhuangzhuang Liu; Xugang Wang; Zhijun Chen; Hui Wang; Marie Malissen; Bernard Malissen;Lichen Zhang*; Yinming Liang*; Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice.PLoS Pathogens, 2022;18(6):e1010596.
