牛玉娜（1982.1-），理學(xué)博士，副教授，碩士生導(dǎo)師，從事自噬與感染免疫、NK細(xì)胞活性調(diào)節(jié)的研究，目前的主要研究方向：1.線粒體自噬在HTLV-1感染過程中作用及其機(jī)制研究；2.細(xì)胞自噬在白血病細(xì)胞耐藥、白血病發(fā)生中的作用和機(jī)制研究；3. NK的活性調(diào)控的機(jī)制研究及新型NK細(xì)胞免疫療法在治療髓細(xì)胞白血病中的應(yīng)用研究。
【受教育經(jīng)歷】
2000.09-2004.06，河南農(nóng)業(yè)大學(xué)，動物科學(xué)，本科
2004.09-2007.06，華中科技大學(xué)，動物遺傳學(xué)，碩士
2007.09-2010.06，中山大學(xué)，動物學(xué)，博士
【研究工作經(jīng)歷】
2015.01-2016.11 中國科學(xué)院上海生命科學(xué)研究院 博士后
2017.02-2017.08 美國杜克大學(xué) 博士后
2017.11-2021.03 新鄉(xiāng)醫(yī)學(xué)院醫(yī)學(xué)檢驗學(xué)院 講師
2021.04-至今 新鄉(xiāng)醫(yī)學(xué)院醫(yī)學(xué)檢驗學(xué)院 副教授
2010.07-2011.07，華大基因研究院
2011.10-2014.09，蘇州大學(xué)唐仲英醫(yī)學(xué)研究院 助理研究員
2014.10-2020.04 新鄉(xiāng)醫(yī)學(xué)院醫(yī)學(xué)檢驗學(xué)院 講師
2014.10-2020.04 新鄉(xiāng)醫(yī)學(xué)院醫(yī)學(xué)檢驗學(xué)院 副教授
【承擔(dān)及完成國家級/省級課題】
1. 河南省自然科學(xué)基金：EVI1通過調(diào)控自噬參與白血病干細(xì)胞的干性維持，2017/01-2018/12, 10萬元，項目編號162300410213，主持
2. 國家自然科學(xué)基金：BCL3通過STAT3調(diào)控NK細(xì)胞的功能和機(jī)制研究，2018/1/1-2020/12/30，20萬元，項目編號81701554，主持
3. 河南省教育廳重點科研項目：河南省高等學(xué)校重點科研項目計劃(項目編號: 21A310011)資助的課題，呼吸鏈解偶聯(lián)劑CCCP抗HTLV-1病毒的作用機(jī)制研究, 2021/1/1-2022/12/30，3萬元，項目編號21A310011，主持
【代表性論著】（#為第一作者，*為通訊作者）
1. Yuna Niu#, Xue Yang, Yifei Chen, Xinyue Jin, Li Li, Yilin Guo, Xuelu Li, Yecheng Xie, Yun Zhang, Hui Wang. EVI1 induces autophagy to promote drug resistance via regulation of ATG7 expression in leukemia cells.Carcinogenesis, 2020 ;41(7):961-971.
2. Yuna Niu#, Xue Yang, Yifei Chen, Linbo Zhang, Xinyue Jin, Youjing Tang, Li Li,Lu Yu, Yilin Guo, Hui Wang. BCL3 expression is a potential prognostic and predictive biomarker in acute myeloid leukemia of FAB Subtype M2. Pathol Oncol Res. 2019 ;25(2):541-548.
3. Yuna Niu#, Xue Yang,YifeiChen,XinyueJin, Yecheng Xie ,Youjing Tang,Li Li,ShiboLiu,YilinGuo,XueluLi,LiangweiDuan,HuiWang. Distinct prognostic values of Annexin family members expression in acute myeloid leukemia.Clin Transl Oncol.2019 ;21(9):1186-1196
4. Yuna Niu#, Qingqing Liu, Suping Zhang, Na Yuan, Yan Cao, Jinyang Cai, Weiwei Lin, Fei Xu, Zhen Wang, Jianrong Wang. Alternative messenger RNA splicing of autophagic gene Beclin 1 in human B-cell acute lymphoblastic leukemia cells. Asian Pac J Cancer Prev. 2014;15(5):2153-8.
5. Yuna Niu#, Delin Mo, Limei Qin, Chong Wang, Anning Li, Xiao Zhao, Xiaoying Wang, Shuqi Xiao, Qiwei Wang, Ying Xie, Zuyong He, Peiqing Cong, Yaosheng Chen*. Lipopolysaccharide-induced miR-1224 negatively regulates tumour necrosis factor-α gene expression by modulating Sp1. Immunology. 2011 ;133(1):8-20.
6. Liangwei Duan, Qianqian Zheng, Zhang H,Yuna Niu, Yunwei Lou, Wang Hui. The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens. Front Immunol. 2020 ;11:576622
7. Yunwei Lou, Han M, Liu H,Yuna Niu, Liang Y, Guo J, Zhang W, Wang H. Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection. Cell Mol Immunol. 2020 ; 17(10):1053-1062.
8. 謝業(yè)成,郭儀琳,李雪露,高靜濤,張碩,段良偉,牛玉娜*.BCL3轉(zhuǎn)錄共激活因子的亞細(xì)胞定位研究.中國細(xì)胞生物學(xué)學(xué)報. 2021;43(08): 1574-1580.
9. 李莉,張藝博,張林波,湯友靜,陳逸飛,關(guān)丫丫,牛玉娜*.BCL3基因敲除對線粒體呼吸作用及ATP合成的影響.中國細(xì)胞生物學(xué)學(xué)報, 2018; 40(4): 533-541.
10. 楊雪,謝業(yè)成,郭儀琳,李雪露劉奐弟,段良偉,牛玉娜*, HTLV-1病毒感染誘導(dǎo)宿主細(xì)胞線粒體損傷.中華微生物學(xué)和免疫學(xué)雜志, 2019;39(12): 898-903.
11. 張林波,牛玉娜,王輝.信號轉(zhuǎn)導(dǎo)與轉(zhuǎn)錄激活因子和腫瘤微環(huán)境對自然殺傷細(xì)胞功能及免疫監(jiān)視影響的研究進(jìn)展.新鄉(xiāng)醫(yī)學(xué)院學(xué)報,2017,;34(11), 1037-1039.
12. 湯友靜,牛玉娜,王輝. Pink1/Parkin介導(dǎo)的線粒體自噬分子機(jī)制.中國細(xì)胞生物學(xué)學(xué)報, 2017;39(7), 939-946.
13. Yun Zhang, Wenqing Tan, Lin Zhang, Shuyou Shi,Yuna Niu, Xue Yang, Jinjuan Qiao, Hui Wang. Highly sensitive and selective colorimetric determination of Staphylococcus aureus via chicken anti-protein A IgY antibody. Analytical Methods, 2019 ;11(29): 3665-3670.
14. Zhijian Wang, Fei Xu, Na Yuan,Yuna Niu, Weiwei Lin, Yan Cao, Jinyang Cai, Lin Song, Xin Li, Yixuan Fang, Wenli Zhao, Shaoyan Hu, Suning Chen, Suping Zhang, Jianrong Wang. Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases. Leuk Res. 2014 ;38(8):940-7.
15. Suping Zhang,Yuna Niu, Na Yuan, Aihong Zhang, Dan Chao, Qiuping Xu, Lijun Wang, Xueguang Zhang, Wenli Zhao, Yun Zhao, Jianrong Wang. Role of autophagy in acute myeloid leukemia therapy. Chinese Journal of Cancer; 2013 ;32(3):130-5.
16. Limei Qin, Yaosheng Chen,Yuna Niu, Weiquan Chen, Qiwei Wang, Shuqi Xiao, Anning Li, Ying Xie, Jing Li, Xiao Zhao, Zuyong He, Delin Mo. A deep investigation into the adipogenesis mechanism: profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/beta-catenin signaling pathway. BMC Genomics. 2010;11:320.
17. Shuqi Xiao, Jianyu Jia, Delin Mo, Qiwei Wang, Limei Qin, Zuyong He, Xiao Zhao, Yuankai Huang, Anning Li, Jingwei Yu,Yuna Niu, Xiaohong Liu, Yaosheng Chen Y. Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing*. PLoS One. 2010 ;5(6):e11377.
18. Shuqi Xiao, Delin Mo, Qiwei Wang, Jianyu Jia, Limei Qin, Xiangchun Yu,Yuna Niu, Xiao Zhao, Xiaohong Liu, Yaosheng Chen. Aberrant host immune response induced by highly virulent PRRSV identified by digital gene expression tag profiling. BMC Genomics. 2020 ;11:544.
19. Xiao Zhao, Delin Mo, Anning Li, Wen Gong, Shuqi Xiao, Yue Zhang, Limei Qin,Yuna Niu, Yunxue Guo, Xiaohong Liu, Peiqing Cong, Zuyong He, Chong Wang, Jiaqi Li, Yaosheng Chen. Comparative analyses by sequencing of transcriptomes during skeletal muscle development between pig breeds differing in muscle growth rate and fatness. PLoS One.2010 ; 6(5):e19774.
20. Anning Li, Yaosheng Chen, Xiao Zhao,Yuna Niu, Peiqing Cong, Zongwu Zhang, Weiquan Chen, Wei Jiang, Delin Mo. Characterization and transcriptional regulation analysis of the porcine TNFAIP8L2 gene. Mol Genet Genomics. Epub. 2010 ;284(3):185-95.
21. Zhisheng Zhang, Delin Mo, Peiqing Cong, Zuyong He, Fei Ling, Anning Li,Yuna Niu, Xiao Zhao, Chunyan Zhou, Yaosheng Chen. Molecular cloning, expression patterns and subcellular localization of porcine TMCO1 gene. Mol Biol Rep. 2010 ;37(3):1611-8.
