趙偉棟，男，1983.06-，2014年畢業(yè)于法國艾克斯-馬賽大學免疫學專業(yè)獲博士學位，2010.03-2014.01在歐洲馬賽免疫學中心完成了博士課題。主要研究方向圍繞食源性沙門氏菌與宿主相互作用來開展，通過運用現(xiàn)代分子生物學、細胞生物學、生物化學等技術及小鼠遺傳學手段來研究沙門氏菌多種毒力因子的分子致病機制。主要包括沙門氏菌毒素-抗毒素模型、抗宿主氧化應激毒力因子及沙門氏菌毒力效應蛋白。熟悉沙門氏菌感染的各種特征特性，在動物模型感染方面積累了良好基礎。以第一及共同作者在PLOS Pathogens、Cellular Microbiology、Molecular Microbiology、Scientific Reports等雜志上發(fā)表論文8篇，目前主持1項國家自然科學基金青年項目。

發(fā)表SCI論文一覽表（#為第一作者，*為通訊作者）

1. Moest T^#, Zhao W^#, Zhao Y, Schüssler JM, Yan W, Gorvel JP, Méresse S*. Contribution of bacterial effectors and host proteins to the composition and function of Salmonella-induced tubules. Cell Microbiol. 2018 Dec;20(12):e12951. doi: 10.1111/cmi.12951.

2. Zhao W^#, Moest T, Zhao Y, Guilhon AA, Buffat C, Gorvel JP, Méresse S*. The Salmonella effector protein SifA plays a dual role in virulence. Sci Rep. 2015 Aug 13;5:12979. doi: 10.1038/srep12979.

3. Zhao W^#, Méresse S*. A method to introduce an internal tag sequence into a Salmonella chromosomal gene. Methods Mol Biol. 2015;1225:81-92. doi: 10.1007/978-1-4939-1625-2_5.

4. Martirosyan A^#, Von Bargen K, Arce Gorvel V, Zhao W, Hanniffy S, Bonnardel J, Méresse S, Gorvel JP*. In Vivo Identification and Characterization of CD4+ Cytotoxic T Cells Induced by Virulent Brucellaabortus Infection. PLoS One. 2013 Dec 19;8(12):e82508. doi: 10.1371/journal.pone.0082508.

5. De la Cruz MA^#, Zhao W, Farenc C, Gimenez G, Raoult D, Cambillau C, Gorvel JP, Méresse S*. A Toxin-AntitoxinModule of SalmonellaPromotesVirulence in Mice. PLoS Pathog. 2013;9(12):e1003827. doi: 10.1371/journal.ppat.1003827.

6. Ordo?ez-Rueda D^#, J?nsson F, Mancardi DA, Zhao W, Malzac A, Liang Y, Bertosio E, Grenot P, Blanquet V, Sabrautzki S, de Angelis MH, Méresse S, Duprez E, Bruhns P, Malissen B, Malissen M*. A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia. Eur J Immunol. 2012 Sep;42(9):2395-408. doi: 10.1002/eji.201242589.

7. Aussel L^#, Zhao W, Hébrard M, Guilhon AA, Viala JP, Henri S, Chasson L, Gorvel JP, Barras F*, Méresse S*. Salmonella detoxifying enzymes are sufficient to cope with the host oxidative burst. Mol Microbiol. 2011 May;80(3):628-40. doi: 10.1111/j.1365-2958.2011.07611.x.

8. Schroeder N^#, Henry T, de Chastellier C, Zhao W, Guilhon AA, Gorvel JP, Méresse S*. The virulence protein SopD2 regulates membrane dynamics of Salmonella-containing vacuoles. PLoS Pathog. 2010 Jul 15;6(7):e1001002. doi: 10.1371/journal.ppat.1001002.

科研項目：

1. 沙門氏菌毒素效應蛋白SifA C-端結構域毒力功能機制的研究，趙偉棟，國家自然科學基金青年項目，2017/01-2019/12，No:31600109，20萬元